NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Near-infrared spectroscopy for monitoring of tissue oxygenation of exercising skeletal muscle in a chronic compartment syndrome modelVariations in the levels of muscle hemoglobin and of myoglobin oxygen saturation can be detected non-invasively with near-infrared spectroscopy. This technique could be applied to the diagnosis of chronic compartment syndrome, in which invasive testing has shown increased intramuscular pressure associated with ischemia and pain during exercise. We simulated chronic compartment syndrome in ten healthy subjects (seven men and three women) by applying external compression, through a wide inflatable cuff, to increase the intramuscular pressure in the anterior compartment of the leg. The tissue oxygenation of the tibialis anterior muscle was measured with near-infrared spectroscopy during gradual inflation of the cuff to a pressure of forty millimeters of mercury (5.33 kilopascals) during fourteen minutes of cyclic isokinetic dorsiflexion and plantar flexion of the ankle. The subjects exercised with and without external compression. The data on tissue oxygenation for each subject then were normalized to a scale of 100 per cent (the baseline value, or the value at rest) to 0 per cent (the physiological minimum, or the level of oxygenation achieved by exercise to exhaustion during arterial occlusion of the lower extremity). With external compression, tissue oxygenation declined at a rate of 1.4 +/- 0.3 per cent per minute (mean and standard error) during exercise. After an initial decrease at the onset, tissue oxygenation did not decline during exercise without compression. The recovery of tissue oxygenation after exercise was twice as slow with compression (2.5 +/- 0.6 minutes) than it was without the use of compression (1.3 +/- 0.2 minutes).
Document ID
20040172952
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Breit, G. A.
(NASA Ames Research Center Moffett Field, CA United States)
Gross, J. H.
Watenpaugh, D. E.
Chance, B.
Hargens, A. R.
Date Acquired
August 22, 2013
Publication Date
June 1, 1997
Publication Information
Publication: The Journal of bone and joint surgery. American volume
Volume: 79
Issue: 6
ISSN: 0021-9355
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL44125-05
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
NASA Center ARC
NASA Discipline Cardiopulmonary

Available Downloads

There are no available downloads for this record.
No Preview Available