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Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canineBACKGROUND: When a pressure overload is placed on the left ventricle, some patients develop relatively modest hypertrophy whereas others develop extensive hypertrophy. Likewise, the occurrence of contractile dysfunction also is variable. The cause of this heterogeneity is not well understood. METHODS AND RESULTS: We recently developed a model of gradual proximal aortic constriction in the adult canine that mimicked the heterogeneity of the hypertrophic response seen in humans. We hypothesized that differences in outcome were related to differences present before banding. Fifteen animals were studied initially. Ten developed left ventricular dysfunction (dys group). Five dogs maintained normal function (nl group). At baseline, the nl group had a lower mean systolic wall stress (96 +/- 9 kdyne/cm2; dys group, 156 +/- 7 kdyne/cm2; P < .0002) and greater relative left ventricular mass (left ventricular weight [g]/body wt [kg], 5.1 +/- 0.36; dys group, 3.9 +/- 0.26; P < .02). On the basis of differences in mean systolic wall stress at baseline, we predicted outcome in the next 28 dogs by using a cutoff of 115 kdyne/cm2. Eighteen of 20 dogs with baseline mean systolic stress > 115 kdyne/cm2 developed dysfunction whereas 6 of 8 dogs with resting stress < or = 115 kdyne/cm2 maintained normal function. CONCLUSIONS: We conclude that this canine model mimicked the heterogeneous hypertrophic response seen in humans. In the group that eventually developed dysfunction there was less cardiac mass despite 60% higher wall stress at baseline, suggesting a different set point for regulating myocardial growth in the two groups.
Document ID
20040173000
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Koide, M.
(Medical University of South Carolina Charleston 29425-2221, United States)
Nagatsu, M.
Zile, M. R.
Hamawaki, M.
Swindle, M. M.
Keech, G.
DeFreyte, G.
Tagawa, H.
Cooper, G. 4th
Carabello, B. A.
Date Acquired
August 22, 2013
Publication Date
March 18, 1997
Publication Information
Publication: Circulation
Volume: 95
Issue: 6
ISSN: 0009-7322
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: PO1-HL-48788
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary

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