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Record 1 of 2211
Effect of gravity on lung exhaled nitric oxide at rest and during exercise
External Online Source: doi:10.1016/S0034-5687(96)02517-0
Author and Affiliation:
Pogliaghi, S.(State University of New York at Buffalo, School of Medicine and Biomedical Sciences 14214, Hermann Rahn Laboratory of Environmental Physiology, Department of Physiology, United States)
Krasney, J. A.
Pendergast, D. R.
Abstract: Exhaled nitric oxide (NO) from the lungs (VNO) in nose-clipped subjects increases during exercise. This may be due to endothelial shear stress secondary to changes in pulmonary blood flow. We measured VNO after modifying pulmonary blood flow with head-out water immersion (WI) or increased gravity (2 Gz) at rest and during exercise. Ten sedentary males were studied during exercise performed in air and WI. Nine subjects were studied at 1 and 2 Gz. Resting NO concentrations in exhaled air ([NO]) were 16.3 +/- 8.2 ppb (air). 15 +/- 8.2 ppb (WI) and 17.4 +/- 5 ppb (2 Gz). VNO (ppb/min) was calculated as [NO]VE and was unchanged at rest by either WI or 2 Gz. VNO increased linearly with Vo2, VE and fii during exercise in air, WI and at 2 Gz. These relationships did not differ among the experimental conditions. Therefore, changes in pulmonary blood flow failed to alter the output of NO exhaled from the lungs at rest or during exercise.
Publication Date: Feb 01, 1997
Document ID:
20040173032
(Acquired Dec 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Respiration physiology (ISSN 0034-5687); Volume 107; 2; 157-64
Publisher Information: Netherlands
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: GRAVITATION; GRAVITATIONAL EFFECTS; LUNGS; METABOLISM; NITRIC OXIDE; PHYSICAL EXERCISE; REST; ADULTS; ALVEOLI; HEART RATE; MALES; OXYGEN CONSUMPTION; PULMONARY CIRCULATION; PULMONARY FUNCTIONS; SUBMERGING
Other Descriptors: EXERCISE/PHYSIOLOGY; GRAVITATION; LUNG/METABOLISM/PHYSIOLOGY; NITRIC OXIDE/METABOLISM; REST/PHYSIOLOGY; ADULT; HEART RATE/PHYSIOLOGY; HUMAN; IMMERSION/PHYSIOPATHOLOGY; MALE; OXYGEN CONSUMPTION/PHYSIOLOGY; PULMONARY ALVEOLI/METABOLISM; PULMONARY CIRCULATION/PHYSIOLOGY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; NASA DISCIPLINE CARDIOPULMONARY; NON-NASA CENTER; CLINICAL TRIAL
Availability Source: Other Sources
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