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Gene regulation by mechanical forcesEndothelial cells are subjected to various mechanical forces in vivo from the flow of blood across the luminal surface of the blood vessel. The purpose of this review was to examine the data available on how these mechanical forces, in particular cyclic strain, affect the expression and regulation of endothelial cell function. Studies from various investigators using models of cyclic strain in vitro have shown that various vasoactive mediators such as nitric oxide and prostacyclin are induced by the effect of mechanical deformation, and that the expression of these mediators may be regulated at the transcription level by mechanical forces. There also seems to be emerging evidence that endothelial cells may also act as mechanotransducers, whereby the transmission of external forces induces various cytoskeletal changes and second messenger cascades. Furthermore, it seems these forces may act on specific response elements of promoter genes.
Document ID
20040173050
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Oluwole, B. O.
(Yale University School of Medicine New Haven, CT 06510, United States)
Du, W.
Mills, I.
Sumpio, B. E.
Date Acquired
August 22, 2013
Publication Date
January 1, 1997
Publication Information
Publication: Endothelium : journal of endothelial cell research
Volume: 5
Issue: 2
ISSN: 1062-3329
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Review
Non-NASA Center
NASA Discipline Cell Biology

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