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Secondary metabolism in simulated microgravity: beta-lactam production by Streptomyces clavuligerusRotating bioreactors designed at NASA's Johnson Space Center were used to simulate a microgravity environment in which to study secondary metabolism. The system examined was beta-lactam antibiotic production by Streptomyces clavuligerus. Both growth and beta-lactam production occurred in simulated microgravity. Stimulatory effects of phosphate and L-lysine, previously detected in normal gravity, also occurred in simulated microgravity. The degree of beta-lactam antibiotic production was markedly inhibited by simulated microgravity.
Document ID
20040173057
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Fang, A.
(Massachusetts Institute of Technology Cambridge 02139, United States)
Pierson, D. L.
Mishra, S. K.
Koenig, D. W.
Demain, A. L.
Date Acquired
August 22, 2013
Publication Date
January 1, 1997
Publication Information
Publication: Journal of industrial microbiology & biotechnology
Volume: 18
Issue: 1
ISSN: 1367-5435
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Environmental Health
NASA Program Environmental Health
NASA Center JSC
NASA Discipline Number 04-10

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