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Predicting sudden cardiac death from T wave alternans of the surface electrocardiogram: promise and pitfallsSudden cardiac death remains a preeminent public health problem. Despite advances in preventative treatment for patients known to be at risk, to date we have been able to identify, and thus treat, only a small minority of these patients. Therefore, there is a major need to develop noninvasive diagnostic technologies to identify patients at risk. Recent studies have demonstrated that measurement of microvolt-level T wave alternans is a promising technique for the accurate identification of patients at risk for ventricular arrhythmias and sudden cardiac death. In this article, we review the clinical data establishing the relationship between microvolt T wave alternans and susceptibility to ventricular arrhythmias. We also review the methods and technology that have been developed to measure microvolt levels of T wave alternans noninvasively in broad populations of ambulatory patients. In particular, we examine techniques that permit the accurate measurement of T wave alternans during exercise stress testing.
Document ID
20040173108
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Rosenbaum, D. S.
(Case Western Reserve University Cleveland, Ohio, United States)
Albrecht, P.
Cohen, R. J.
Date Acquired
August 22, 2013
Publication Date
November 1, 1996
Publication Information
Publication: Journal of cardiovascular electrophysiology
Volume: 7
Issue: 11
ISSN: 1045-3873
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Non-NASA Center
NASA Discipline Regulatory Physiology
Review

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