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Record Details

Record 94 of 982
Noninvasive markers of bone metabolism in the rhesus monkey: normal effects of age and gender
Author and Affiliation:
Cahoon, S.(Emory University School of Medicine, Yerkes Regional Primate Center, Department of Orthopaedic Surgery, Atlanta, GA)
Boden, S. D.
Gould, K. G.
Vailas, A. C.
Abstract: Measurement of bone turnover in conditions such as osteoporosis has been limited by the need for invasive iliac bone biopsy to reliably determine parameters of bone metabolism. Recent advances in the area of serum and urinary markers of bone metabolism have raised the possibility for noninvasive measurements; however, little nonhuman primate data exist for these parameters. The purpose of this experiment was to define the normal range and variability of several of the newer noninvasive bone markers which are currently under investigation in humans. The primary intent was to determine age and gender variability, as well as provide some normative data for future experiments in nonhuman primates. Twenty-four rhesus macaques were divided into equal groups of male and female according to the following age groupings: 3 years, 5-10 years, 15-20 years, and > 25 years. Urine was collected three times daily for a four-day period and measured for several markers of bone turnoverm including pyridinoline (PYD), deoxypyrodinoline (DPD), hydroxyproline, and creatinine. Bone mineral density measurements of the lumbar spine were performed at the beginning and end of the study period. Serum was also obtained at the time of bone densitometry for measurement of osteocalcin levels by radioimmunoassay. There were no significant differences in bone mineral density, urine PYD, or urine DPD based on gender. Bone density was lowest in the youngest animals, peaked in the 15-20-year group, but again decreased in the oldest animals. The osteocalcin, PYD, and DPD levels followed an inversely related pattern to bone density. The most important result was the relative age insensitivity of the ratio of PYD:DPD in monkeys up to age 20 years. Since bone density changes take months or years to become measurable and iliac biopsies are invasive, the PYD/DPD marker ratio may have important implications for rapid noninvasive measurement of the effects of potential treatments for osteoporosis in the non-human primate model.
Publication Date: Oct 01, 1996
Document ID:
20040173119
(Acquired Dec 09, 2004)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Journal of medical primatology (ISSN 0047-2565); Volume 25; 5; 333-8
Publisher Information: Denmark
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AGE FACTOR; BONE MINERAL CONTENT; BONES; MARKERS; METABOLISM; MONKEYS; OSTEOPOROSIS; SEX FACTOR; AEROSPACE MEDICINE; BIOASTRONAUTICS; BIOMARKERS; DISEASES; FEMALES; MALES; OSTEOCALCIN
Other Descriptors: BONE DENSITY/PHYSIOLOGY; MACACA MULATTA/METABOLISM; OSTEOPOROSIS/PHYSIOPATHOLOGY; PYRIDINIUM COMPOUNDS/URINE; AGE FACTORS; ANIMALS; BIOLOGICAL MARKERS/URINE; DISEASE MODELS, ANIMAL; FEMALE; MALE; OSTEOCALCIN/BLOOD; REFERENCE VALUES; SEX FACTORS; SUPPORT, U.S. GOV'T, NON-P.H.S; NASA DISCIPLINE MUSCULOSKELETAL; NASA DISCIPLINE NUMBER 26-10; NASA PROGRAM SPACE PHYSIOLOGY AND COUNTERMEASURES; NON-NASA CENTER
Availability Source: Other Sources
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