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Effects of spaceflight on rat peripheral blood leukocytes and bone marrow progenitor cellsThe white blood cell (WBC) elements and the bone marrow myeloid progenitor cell populations were analyzed to ascertain adaptation to micro-gravity and subsequent readaptation to 1 G in rats flown on the 14-day Spacelab Life Sciences-2 (SLS-2) mission. Bone marrow cells were harvested from one group of rats killed inflight (FD13) and blood was drawn from three other groups at various times. The WBC level was normal on FD14 with the exception of neutrophilia. On FD13, numbers of colony-forming units-granulocyte (CFU-G), CFU-GM, and CFU-M from flight animals were decreased compared with ground controls when incubated with recombinant rat interleukin-3 (rrIL-3) alone or in combination with recombinant human erythropoietin (rhEpo). On recovery (R + 0), flight rats had decreased numbers of total leukocytes and absolute numbers of lymphocytes and monocytes with elevated neutrophils compared with control rats. They had lower numbers of CD4, CD8, CD2, CD3, and B cells in the peripheral blood but no differences in spleen lymphocytes.
Document ID
20040173185
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ichiki, A. T.
(Graduate School of Medicine, University of Tennessee Medical Center at Knoxville United States)
Gibson, L. A.
Jago, T. L.
Strickland, K. M.
Johnson, D. L.
Lange, R. D.
Allebban, Z.
Date Acquired
August 22, 2013
Publication Date
July 1, 1996
Publication Information
Publication: Journal of leukocyte biology
Volume: 60
Issue: 1
ISSN: 0741-5400
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 00-00
STS-58 Shuttle Project
NASA Program Flight
Flight Experiment
manned
NASA Discipline Regulatory Physiology
Non-NASA Center
short duration

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