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Record Details

Record 60 of 2837
Influence of spaceflight on succinate dehydrogenase activity and soma size of rat ventral horn neurons
Author and Affiliation:
Ishihara, A.(Kyoto University, Laboratory of Neurochemistry, Faculty of Integrated Human Studies, Japan)
Ohira, Y.
Roy, R. R.
Nagaoka, S.
Sekiguchi, C.
Hinds, W. E.
Edgerton, V. R.
Abstract: Succinate dehydrogenase (SDH) activities and soma cross-sectional areas (CSA) of neurons in the dorsolateral region of the ventral horn at the L5 segmental level of the spinal cord in the rat were determined after 14 days of spaceflight and after 9 days of recovery on earth. The results were compared to those in age-matched ground-based control rats. Spinal cords were quick-frozen, and the SDH activity and CSA of a sample of neurons with a visible nucleus were determined using a digitizer and a computer-assisted image analysis system. An inverse relationship between CSA and SDH activity of neurons was observed in all groups of rats. No change in mean CSA or mean SDH activity or in the size distribution of neurons was observed following spaceflight or recovery. However, there was a selective decrease in the SDH activity of neurons with soma CSA between 500 and 800 microns2 in the flight rats, and this effect persisted for at least 9 days following return to 1 g. It remains to be determined whether the selected population of motoneurons or the specific motor pools affected by spaceflight may be restricted to specific muscles.
Publication Date: Jan 01, 1996
Document ID:
20040173285
(Acquired Dec 09, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Acta anatomica (ISSN 0001-5180); Volume 157; 4; 303-8
Publisher Information: Switzerland
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CYTOLOGY; DEHYDROGENASES; NEURONS; RATS; SPACEBORNE EXPERIMENTS; SPINAL CORD; COSMOS SATELLITES; LUMBAR REGION; MALES; SPACE SHUTTLE MISSIONS
Other Descriptors: ANTERIOR HORN CELLS/ENZYMOLOGY; NEURONS/CYTOLOGY/ENZYMOLOGY; SPACE FLIGHT; SPINAL CORD/CYTOLOGY/METABOLISM; SUCCINATE DEHYDROGENASE/METABOLISM; ANIMALS; LUMBOSACRAL REGION; MALE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER; COSMOS 2044 PROJECT; FLIGHT EXPERIMENT; STS-58 SHUTTLE PROJECT; MANNED; SHORT DURATION; UNMANNED
Availability Source: Other Sources
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