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Record Details

Record 85 of 1710
Synergistic ablation does not affect atrophy or altered myosin heavy chain expression in the non-weight bearing soleus muscle
External Online Source: doi:10.1016/0024-3205(96)00369-4
Author and Affiliation:
Linderman, J. K.(NASA Ames Research Center, Moffett Field, CA United States)
Talmadge, R. J.
Gosselink, K. L.
Tri, P. N.
Roy, R. R.
Grindeland, R. E.
Abstract: The purpose of this study was to investigate whether the soleus muscle undergoes atrophy and alterations in myosin heavy chain (MHC) composition during non-weight bearing in the absence of synergists. Thirty-two female rats were randomly assigned to four groups: control (C), synergistic ablation (ABL) of the gastrocnemius and plantaris muscles to overload the soleus muscle, hindlimb suspension (HLS), or a combination of synergistic ablation and hindlimb suspension (HLS-ABL). After 28 days of hindlimb suspension, soleus atrophy was more pronounced in HLS (58%) than in HLS-ABL (43%) rats. Compared to C rats, non-weight bearing decreased mixed and myofibrillar protein contents and Type I MHC 49%, 45%, and 7%, respectively, in HLS animals. In addition, de novo expression of fast Type IIx and Type IIb MHC (5% and 2%, respectively) was observed in HLS animals. Similarly, when compared to C rats, mixed and myofibrillar protein contents and Type I MHC decreased 43%, 46%, and 4%, respectively, in HLS-ABL animals. Also, de novo expression of Type IIx (4%) and IIb (1%) MHC was observed. Collectively, these data indicate that the loss of muscle protein and Type I MHC, and the de novo expression of Type IIx and Type IIb MHC in the rat soleus occur independently of the presence of synergists during non-weight bearing. Furthermore, these results confirm the contention that soleus mass and MHC expression are highly sensitive to alterations in mechanical load.
Publication Date: Jan 01, 1996
Document ID:
20040173309
(Acquired Dec 09, 2004)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Life sciences; p. 789-95; (ISSN 0024-3205); Volume 59; 10
Publisher Information: United Kingdom
Contract/Grant/Task Num: DE07212
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ABLATION; ATROPHY; METABOLISM; MUSCLES; MYOSINS; SKELETAL MUSCLE; AEROSPACE MEDICINE; BIOASTRONAUTICS; FEMALES; IMMOBILIZATION; LOAD CARRYING CAPACITY; ORGAN WEIGHT; PATHOLOGY; PROTEINS; RATS
Other Descriptors: MUSCLE, SKELETAL/METABOLISM/PATHOLOGY/PHYSIOPATHOLOGY; MYOSIN HEAVY CHAINS/BIOSYNTHESIS; ANIMALS; ATROPHY; FEMALE; IMMOBILIZATION; MUSCLE PROTEINS/BIOSYNTHESIS; ORGAN WEIGHT; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; WEIGHT-BEARING; NASA CENTER ARC; NASA DISCIPLINE MUSCULOSKELETAL; NASA DISCIPLINE NUMBER 26-10; NASA PROGRAM SPACE PHYSIOLOGY AND COUNTERMEASURES
Availability Source: Other Sources
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