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Pyridoxic acid excretion during low vitamin B-6 intake, total fasting, and bed restVitamin B-6 metabolism in 10 volunteers during 21 d of total fasting was compared with results from 10 men consuming a diet low only in vitamin B-6 (1.76 mumol/d) and with men consuming a normal diet during bed rest. At the end of the fast mean plasma concentrations of vitamin B-6 metabolites and urinary excretion of 4-pyridoxic acid tended to be higher in the fasting subjects than in the low-vitamin B-6 group. The fasting subjects lost approximately 10% of their total vitamin B-6 pool and approximately 13% of their body weight. The low-vitamin B-6 group lost only approximately 4% of their vitamin B-6 pool. Compared with baseline, urinary excretion of pyridoxic acid was significantly increased during 17 wk of bed rest. There was no increase in pyridoxic acid excretion during a second 15-d bed rest study. These data suggest the possibility of complex interactions between diet and muscle metabolism that may influence indexes that are frequently used to assess vitamin B-6 status.
Document ID
20040173346
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Coburn, S. P.
(Fort Wayne State Developmental Center IN, United States)
Thampy, K. G.
Lane, H. W.
Conn, P. S.
Ziegler, P. J.
Costill, D. L.
Mahuren, J. D.
Fink, W. J.
Pearson, D. R.
Schaltenbrand, W. E.
Date Acquired
August 22, 2013
Publication Date
November 1, 1995
Publication Information
Publication: The American journal of clinical nutrition
Volume: 62
Issue: 5
ISSN: 0002-9165
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
NASA Center JSC

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