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Circadian rhythms of temperature and activity in obese and lean Zucker ratsThe circadian timing system is important in the regulation of feeding and metabolism, both of which are aberrant in the obese Zucker rat. This study tested the hypothesis that these abnormalities involve a deficit in circadian regulation by examining the circadian rhythms of body temperature and activity in lean and obese Zucker rats exposed to normal light-dark cycles, constant light, and constant dark. Significant deficits in both daily mean and circadian amplitude of temperature and activity were found in obese Zucker female rats relative to lean controls in all lighting conditions. However, the circadian period of obese Zucker rats did not exhibit differences relative to lean controls in either of the constant lighting conditions. These results indicate that although the circadian regulation of temperature and activity in obese Zucker female rats is in fact depressed, obese rats do exhibit normal entrainment and pacemaker functions in the circadian timing system. The results suggest a deficit in the process that generates the amplitude of the circadian rhythm.
Document ID
20040173347
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Murakami, D. M.
(University of California Davis 95616-8519, United States)
Horwitz, B. A.
Fuller, C. A.
Date Acquired
August 22, 2013
Publication Date
November 1, 1995
Publication Information
Publication: The American journal of physiology
Volume: 269
Issue: 5 Pt 2
ISSN: 0002-9513
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DK-35747
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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