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Expression of S100 beta in sensory and secretory cells of the vertebrate inner earWe evaluated anti-S100 beta expression in the chick (Gallus domesticus) inner ear and determined that: 1) the monomer anti-S100 beta is expressed differentially in the vestibular and auditory perikarya; 2) expression of S100 beta in the afferent nerve terminals is time-related to synapse and myelin formation; 3) the expression of the dimer anti-S100 alpha alpha beta beta and monomer anti-S100 beta overlaps in most inner ear cell types. Most S100 alpha alpha beta beta positive cells express S100 beta, but S100 beta positive cells do not always express S100 alpha alpha beta beta. 4) the expression of S100 beta is diffused over the perikaryal cytoplasm and nuclei of the acoustic ganglia but is concentrated over the nuclei of the vestibular perikarya. 6) S100 beta is expressed in secretory cells, and it is co-localized with GABA in sensory cells. 7) Color thresholding objective quantitation indicates that the amount of S100 beta was higher (mean 22, SD +/- 4) at E19 than at E9 (mean 34, SD +/- 3) in afferent axons. 8) Moreover, S100 beta was unchanged between E11-E19 in the perikaryal cytoplasm, but did change over the nuclei. At E9, 74%, and at E21, 5% of vestibular perikarya were positive. The data suggest that S100 beta may be physically associated with neuronal and ionic controlling cells of the vertebrate inner ear, where it could provide a dual ionic and neurotrophic modulatory function.
Document ID
20050000224
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Fermin, C. D.
(Tulane University School of Medicine, Department of Pathology & Laboratory Medicine New Orleans, LA 70112-2699, United States)
Martin, D. S.
Date Acquired
August 22, 2013
Publication Date
March 1, 1995
Publication Information
Publication: Cellular and molecular biology (Noisy-le-Grand, France)
Volume: 41
Issue: 2
ISSN: 0145-5680
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 40-10
NASA Program Space Biology
NASA Discipline Neuroscience
Non-NASA Center

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