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connective tissue integrity is lost in vitamin b-6-deficient chicksThe objective of the present investigation was to characterize further the connective tissue disorder produced by pyridoxine (vitamin B-6) deficiency, as previously evidenced by electron microscopy. Following the second post-natal week, fast growing male chicks were deprived of pyridoxine for a 1-mo period. Six weeks post-natally, blood concentrations in the experimental deficiency group had declined to deficiency levels as registered by low concentrations of pyridoxal phosphate (coenzyme form) in erythrocytes, but did not reach levels associated with neurological symptoms. Light microscopic study showed abnormalities in the extracellular matrix of the connective tissues. Collagen cross-links and the aldehyde contents were not significantly lower in cartilage and tendon collagens of vitamin B-6-deficient animals than in age-matched controls; also, their proteoglycan degrading protease and collagenase activities measured in articular cartilages were not greater. Thus, proteolysis was an unlikely alternative mechanism to account for the loss of connective tissue integrity. These results point to the need for further investigation into adhesive properties of collagen associated proteoglycans or other proteins in vitamin B-6-deficient connective tissue.
Document ID
Document Type
Reprint (Version printed in journal)
Masse, P. G.
(Universite de Moncton New Brunswick, Canada)
Yamauchi, M.
Mahuren, J. D.
Coburn, S. P.
Muniz, O. E.
Howell, D. S.
Date Acquired
August 22, 2013
Publication Date
January 1, 1995
Publication Information
Publication: The Journal of nutrition
Volume: 125
Issue: 1
ISSN: 0022-3166
Subject Category
Life Sciences (General)
Funding Number(s)
Distribution Limits
Non-NASA Center
NASA Discipline Musculoskeletal