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Selective cytotoxicity of transformed cells but not normal cells by a sialoglycopeptide growth regulator in the presence of tumor necrosis factorThe tumor necrosis factor-alpha (TNF)-resistant, SV40-transformed, murine fibroblast cell lines, F5b and F5m, became sensitive to TNF-mediated cytolysis after treatment with a biologically active 18 kDa peptide fragment (SGP) derived from a 66-kDa parental cell surface sialoglycoprotein. Neither TNF nor the SGP alone exhibited cytotoxicity to the two SV40-transformed cell lines. However, Balb/c 3T3 cells, incubated with SGP alone or with SGP and TNF, were not killed. Therefore, SGP can selectively sensitize cells for TNF alpha-mediated cytotoxicity. This selective sensitization may be due to the previously documented ability of the SGP to selectively mediate cell cycle arrest.
Document ID
Document Type
Reprint (Version printed in journal)
External Source(s)
Woods, K. M.
(Kansas State University Manhattan 66506)
Fattaey, H.
Johnson, T. C.
Chapes, S. K.
Spooner, B. S.
Date Acquired
August 22, 2013
Publication Date
November 30, 1994
Publication Information
Publication: Biochemical and biophysical research communications
Volume: 205
Issue: 1
ISSN: 0006-291X
Subject Category
Life Sciences (General)
Distribution Limits
NASA Discipline Cell Biology
Non-NASA Center
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