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Crystal structure of a four-stranded intercalated DNA: d(C4)The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
Document ID
20050000288
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Chen, L.
(Massachusetts Institute of Technology Cambridge 02139)
Cai, L.
Zhang, X.
Rich, A.
Date Acquired
August 22, 2013
Publication Date
November 22, 1994
Publication Information
Publication: Biochemistry
Volume: 33
Issue: 46
ISSN: 0006-2960
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Exobiology

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