NASA Logo, External Link
Facebook icon, External Link to NASA STI page on Facebook Twitter icon, External Link to NASA STI on Twitter YouTube icon, External Link to NASA STI Channel on YouTube RSS icon, External Link to New NASA STI RSS Feed AddThis share icon
 

Record Details

Record 1 of 2248
Radiation-induced genomic instability
Author and Affiliation:
Kronenberg, A.(Lawrence Berkeley Laboratory, Life Sciences Division, Berkeley, CA 94720)
Abstract: Quantitative assessment of the heritable somatic effects of ionizing radiation exposures has relied upon the assumption that radiation-induced lesions were 'fixed' in the DNA prior to the first postirradiation mitosis. Lesion conversion was thought to occur during the initial round of DNA replication or as a consequence of error-prone enzymatic processing of lesions. The standard experimental protocols for the assessment of a variety of radiation-induced endpoints (cell death, specific locus mutations, neoplastic transformation and chromosome aberrations) evaluate these various endpoints at a single snapshot in time. In contrast with the aforementioned approaches, some studies have specifically assessed radiation effects as a function of time following exposure. Evidence has accumulated in support of the hypothesis that radiation exposure induces a persistent destabilization of the genome. This instability has been observed as a delayed expression of lethal mutations, as an enhanced rate of accumulation of non-lethal heritable alterations, and as a progressive intraclonal chromosomal heterogeneity. The genetic controls and biochemical mechanisms underlying radiation-induced genomic instability have not yet been delineated. The aim is to integrate the accumulated evidence that suggests that radiation exposure has a persistent effect on the stability of the mammalian genome.
Publication Date: Nov 01, 1994
Document ID:
20050000289
(Acquired Jan 06, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: International journal of radiation biology; p. 603-9; (ISSN 0955-3002); Volume 66; 5
Publisher Information: United Kingdom
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: GENES; GENOME; NEOPLASMS; RADIATION EFFECTS; CHROMOSOME ABERRATIONS; MUTATIONS
Other Descriptors: GENES/RADIATION EFFECTS; NEOPLASMS, RADIATION-INDUCED/ETIOLOGY; ANIMALS; CHROMOSOME ABERRATIONS; HUMAN; MUTATION; RECOMBINATION, GENETIC; NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER
Availability Source: Other Sources
› Back to Top
Find Similar Records
NASA Logo, External Link
NASA Official: Gerald Steeman
Site Curator: STI Program
Last Modified: August 23, 2011
Contact Us