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Record Details

Record 4 of 91
Cell proliferation inhibition in reduced gravity
External Online Source: doi:10.1006/excr.1994.1223
Author and Affiliation:
Moos, P. J.(Division of Biology, BioServe Space Technologies, Manhattan, Kansas 66506)
Fattaey, H. K.
Johnson, T. C.
Spooner, B. S. [Principal Investigator]
Abstract: Extended durations of spaceflight have been shown to be deleterious on an organismic level; however, mechanisms underlying cellular sensitivity to the gravitational environment remain to be elucidated. The majority of the gravitational studies to date indicates that cell regulatory pathways may be influenced by their gravitational environment. Still, few cell biology experiments have been performed in space flight and even fewer experiments have been repeated on subsequent flights. With flight opportunities on STS-50, 54, and 57, Sf9 cells were flown in the BioServe Fluids Processing Apparatus and cell proliferation was measured with and without exposure to a cell regulatory sialoglycopeptide (CeReS) inhibitor. Results from these flights indicate that the Sf9 cells grew comparable to ground controls, that the CeReS inhibitor bound to its specific receptor, and that its signal transduction cascade was not gravity sensitive.
Publication Date: Aug 01, 1994
Document ID:
20050000312
(Acquired Jan 06, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Experimental cell research (ISSN 0014-4827); Volume 213; 2; 458-62
Publisher Information: United States
Contract/Grant/Task Num: NCI CA09418
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CELL DIVISION; CELLS (BIOLOGY); CULTURED CELLS; GRAVITATION; MICROGRAVITY; REGENERATION (PHYSIOLOGY); CATTLE; MOTHS; SPACE SHUTTLE MISSIONS
Other Descriptors: CELL DIVISION/DRUG EFFECTS; CELL LINE/CYTOLOGY; GRAVITATION; SIALOGLYCOPROTEINS/PHARMACOLOGY; ANIMALS; CATTLE; MOTHS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER; FLIGHT EXPERIMENT; STS-50 SHUTTLE PROJECT; STS-54 SHUTTLE PROJECT; STS-57 SHUTTLE PROJECT; MANNED; SHORT DURATION
Availability Source: Other Sources
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