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Gravity in mammalian organ development: differentiation of cultured lung and pancreas rudiments during spaceflightOrgan culture of embryonic mouse lung and pancreas rudiments has been used to investigate development and differentiation, and to assess the effects of microgravity on culture differentiation, during orbital spaceflight of the shuttle Endeavour (mission STS-54). Lung rudiments continue to grow and branch during spaceflight, an initial result that should allow future detailed study of lung morphogenesis in microgravity. Cultured embryonic pancreas undergoes characteristic exocrine acinar tissue and endocrine islet tissue differentiation during spaceflight, and in ground controls. The rudiments developing in the microgravity environment of spaceflight appear to grow larger than their ground counterparts, and they may have differentiated more rapidly than controls, as judged by exocrine zymogen granule presence.
Document ID
20050000331
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Spooner, B. S.
(Kansas State University Manhattan 66506-4901)
Hardman, P.
Paulsen, A.
Date Acquired
August 22, 2013
Publication Date
July 1, 1994
Publication Information
Publication: The Journal of experimental zoology
Volume: 269
Issue: 3
ISSN: 0022-104X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
STS-54 Shuttle Project
Non-NASA Center
Flight Experiment
short duration
NASA Discipline Developmental Biology
manned

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