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Record Details

Record 28 of 3007
Negative regulators of cell proliferation
External Online Source: doi:10.1016/0163-7258(94)90013-2
Author and Affiliation:
Johnson, T. C.(Kansas State University, Center for Basic Cancer Research, Manhattan 66506)
Spooner, B. S. [Principal Investigator]
Abstract: Cell proliferation is governed by the influence of both mitogens and inhibitors. Although cell contact has long been thought to play a fundamental role in cell cycling regulation, and negative regulators have long been suspected to exist, their isolation and purification has been complicated by a variety of technical difficulties. Nevertheless, over recent years an ever-expanding list of putative negative regulators have emerged. In many cases, their biological inhibitory activities are consistent with density-dependent growth inhibition. Most likely their interactions with mitogenic agents, at an intracellular level, are responsible for either mitotic arrest or continued cell cycling. A review of naturally occurring cell growth inhibitors is presented with an emphasis on those factors shown to be residents of the cell surface membrane. Particular attention is focused on a cell surface sialoglycopeptide, isolated from intact bovine cerebral cortex cells, which has been shown to inhibit the proliferation of an unusually wide range of target cells. The glycopeptide arrest cells obtained from diverse species, both fibroblasts and epithelial cells, and a broad variety of transformed cells. Signal transduction events and a limited spectrum of cells that are refractory to the sialoglycopeptide have provided insight into the molecular events mediated by this cell surface inhibitor.
Publication Date: Apr 01, 1994
Document ID:
20050000369
(Acquired Jan 06, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Pharmacology & therapeutics (ISSN 0163-7258); Volume 62; 1-2; 247-65
Publisher Information: United Kingdom
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CELL DIVISION; CELLS (BIOLOGY); INHIBITORS; REGENERATION (PHYSIOLOGY); REGULATORS; CATTLE; CULTURED CELLS; DIFFERENTIATION (BIOLOGY); MICE; PEPTIDES; SIGNAL TRANSMISSION; TUMORS
Other Descriptors: CARRIER PROTEINS; CELL DIVISION/DRUG EFFECTS; GROWTH INHIBITORS/TOXICITY; MITOGENS/TOXICITY; ANIMALS; CATTLE; CELL CYCLE/DRUG EFFECTS; CELL DIFFERENTIATION/DRUG EFFECTS; GROWTH SUBSTANCES/TOXICITY; HUMAN; MICE; PEPTIDES/TOXICITY; SIALOGLYCOPROTEINS/TOXICITY; SIGNAL TRANSDUCTION/DRUG EFFECTS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; TUMOR CELLS, CULTURED; NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER; REVIEW; REVIEW, TUTORIAL
Availability Source: Other Sources
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