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Elastin cross-linking in the skin from patients with amyotrophic lateral sclerosisTwo cross-links unique to elastin, desmosine and isodesmosine were measured and compared in skin tissue (left upper arm) from 10 patients with amyotrophic lateral sclerosis (ALS) and from seven age-matched controls. The contents of desmosine and isodesmosine were significantly decreased (p < 0.01 and p < 0.01, respectively) in patients with ALS compared with those of controls, and were negatively and significantly associated with duration of illness in ALS patients (r = -0.77, p < 0.01 and r = -0.65, p < 0.05, respectively). The decline in skin desmosine and isodesmosine is more rapid in ALS than in normal ageing. Thus cross-linking of skin elastin is affected in ALS.
Document ID
20050000382
Document Type
Reprint (Version printed in journal)
Authors
Ono, S. (Teikyo University School of Medicine, Ichihara Hospital Japan)
Yamauchi, M.
Date Acquired
August 22, 2013
Publication Date
January 1, 1994
Publication Information
Publication: Journal of neurology, neurosurgery, and psychiatry
Volume: 57
Issue: 1
ISSN: 0022-3050
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DE 08522
CONTRACT_GRANT: DE 08611
CONTRACT_GRANT: AR 19969
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal