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Immune changes in test animals during spaceflightOver the past two decades, it has become apparent that changes in immune parameters occur in cosmonauts and astronauts after spaceflight. Therefore, interest has been generated in the use of animal surrogates to better understand the nature and extent of these changes, the mechanism of these changes, and to allow the possible development of countermeasures. Among the changes noted in animals after spaceflight are alterations in lymphocytic blastogenesis, cytokine function, natural killer cell activity, and colony-stimulating factors. The nature and significance of spaceflight-induced changes in immune responses will be the focus of this review.
Document ID
20050000429
Document Type
Reprint (Version printed in journal)
Authors
Lesnyak, A. T. (Institute of Biomedical Problems Moscow, Russia)
Sonnenfeld, G.
Rykova, M. P.
Meshkov, D. O.
Mastro, A.
Konstantinova, I.
Date Acquired
August 22, 2013
Publication Date
September 1, 1993
Publication Information
Publication: Journal of leukocyte biology
Volume: 54
Issue: 3
ISSN: 0741-5400
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Cosmos Project
Review
unmanned
NASA Discipline Number 18-10
Review, Tutorial
NASA Discipline Number 00-00
manned
NASA Discipline Regulatory Physiology
STS-51B Shuttle Project
Flight Experiment
Non-NASA Center
NASA Program Flight
short duration
NASA Program Space Physiology and Countermeasures