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Record 8 of 1359
Overview of spaceflight immunology studies
Author and Affiliation:
Taylor, G. R.(NASA Johnson Space Center, Houston, TX United States)
Abstract: The effects of spaceflight and analogues of spaceflight are discussed here and in nine accompanying articles. In this summary we present spaceflight studies with human subjects, animal subjects, and cell cultures and we review ground-based systems used to model the observed effects of spaceflight on the immune system. Human paradigms include bed rest, academic or psychological stress, physical stress, hypobaric or high altitude stress, and confinement. Animal models include antiorthostatic and orthostatic suspension, hypobarism, and confinement. The ten manuscripts in this collection were selected to provide a summary that should give the reader an overview of the various activities of spaceflight immunology researchers throughout the history of space travel. This manuscript identifies the major contributors to the study of spaceflight immunology, explains what types of studies have been conducted, and how they have changed over the years. Also presented is a discussion of the unusual limitations associated with spaceflight research and the efforts to develop appropriate ground-based surrogate model systems. Specific details, data, and mechanistic speculations will be held to a minimum, because they will be discussed in depth in the other articles in the collection.
Publication Date: Sep 01, 1993
Document ID:
20050000430
(Acquired Jan 06, 2005)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Journal of leukocyte biology; p. 179-88; (ISSN 0741-5400); Volume 54; 3
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: IMMUNE SYSTEMS; IMMUNOLOGY; SPACE FLIGHT; AEROSPACE MEDICINE; APOLLO PROJECT; BIOASTRONAUTICS; LONG DURATION SPACE FLIGHT; MIR SPACE STATION; MODELS; SALYUT SPACE STATION; SPACE SHUTTLE MISSIONS
Other Descriptors: IMMUNE SYSTEM/PHYSIOLOGY; SPACE FLIGHT; ANIMALS; HUMAN; MODELS, BIOLOGICAL; NASA CENTER JSC; NASA DISCIPLINE NUMBER 18-10; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NASA PROGRAM SPACE PHYSIOLOGY AND COUNTERMEASURES; APOLLO PROJECT; FLIGHT EXPERIMENT; MIR PROJECT; STS SHUTTLE PROJECT; SALYUT PROJECT; LONG DURATION; MANNED; SHORT DURATION; REVIEW; REVIEW, TUTORIAL
Availability Source: Other Sources
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