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The potential role of salt abuse on the risk for kidney stone formationThe kidney stone-forming risk of a high sodium diet was evaluated by assessing the effect of such a diet on the crystallization of stone-forming salts in urine. Fourteen normal subjects participated in 2 phases of study of 10 days duration each, comprising a low sodium phase (basal metabolic diet containing 50 mmol. sodium per day) and a high sodium phase (basal diet plus 250 mmol. sodium chloride per day). The high sodium intake significantly increased urinary sodium (34 +/- 12 to 267 +/- 56 mmol. per day), calcium (2.73 +/- 1.03 to 3.93 +/- 1.51 mmol. per day) and pH (5.79 +/- 0.44 to 6.15 +/- 0.25), and significantly decreased urinary citrate (3.14 +/- 1.19 to 2.52 +/- 0.83 mmol. per day). Arterialized venous blood bicarbonate and total serum carbon dioxide concentrations decreased significantly during the high sodium diet, whereas serum chloride concentration increased. However, no change in arterialized venous pH was detected. Thus, a high sodium intake not only increased calcium excretion, but also increased urinary pH and decreased citrate excretion. The latter effects are probably due to sodium-induced bicarbonaturia and a significant decrease in serum bicarbonate concentration, respectively. Commensurate with these changes, the urinary saturation of calcium phosphate (brushite) and monosodium urate increased, and the inhibitor activity against calcium oxalate crystallization (formation product) decreased. The net effect of a high sodium diet was an increased propensity for the crystallization of calcium salts in urine.
Document ID
20050000443
Document Type
Reprint (Version printed in journal)
Authors
Sakhaee, K. (Southwestern Medical School, University of Texas Southwestern Medical Center Dallas)
Harvey, J. A.
Padalino, P. K.
Whitson, P.
Pak, C. Y.
Date Acquired
August 22, 2013
Publication Date
August 1, 1993
Publication Information
Publication: The Journal of urology
Volume: 150
Issue: 2 Pt 1
ISSN: 0022-5347
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: M01-RR00633
CONTRACT_GRANT: P01-DK20543
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Number 18-10
NASA Discipline Regulatory Physiology
NASA Center JSC
NASA Program Space Physiology and Countermeasures