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The presence of lysylpyridinoline in the hypertrophic cartilage of newly hatched chicksThe presence of lysylpyridinoline (LP) as a nonreducible cross-link in appreciable quantities has primarily been limited to the mineralized tissues, bone and dentin. However, the results reported here show that LP is not only present in the hypertrophic cartilage of the tibiotarsus isolated from newly hatched broiler chicks, but it is approx. 4-fold as concentrated as hydroxylysylpyridinoline (HP). Bone and articular cartilage surrounding the hypertrophic cartilage do not contain measurable quantities of LP. Purified LP has a fluorescent scan similar to purified HP and literature values, confirming that we indeed were measuring LP. Also, the cartilage lesion produced by immature chondrocytes from birds with tibial dyschondroplasia had LP but the HP:LP ratio was > 1. Thus, the low HP:LP ratio could be a marker for hypertrophic cartilage in avians.
Document ID
Document Type
Reprint (Version printed in journal)
Orth, M. W. (University of Wisconsin-Madison)
Martinez, D. A.
Cook, M. E.
Vailas, A. C.
Date Acquired
August 22, 2013
Publication Date
July 11, 1993
Publication Information
Publication: Biochimica et biophysica acta
Volume: 1157
Issue: 3
ISSN: 0006-3002
Subject Category
Aerospace Medicine
Distribution Limits
NASA Discipline Musculoskeletal
Non-NASA Center
NASA Program Space Physiology and Countermeasures
NASA Discipline Number 26-10