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Increased technetium uptake is not equivalent to muscle necrosis: scintigraphic, morphological and intramuscular pressure analyses of sore muscles after exercise
Author and Affiliation:
Crenshaw, A. G.(University of Umea, Department of Anatomy, Sweden)
Friden, J.
Hargens, A. R.
Lang, G. H.
Thornell, L. E.
Abstract: A scintigraphic technique employing technetium pyrophosphate uptake was used to identify the area of skeletal muscle damage in the lower leg of four runners 24 h after an ultramarathon footrace (160 km). Most of the race had been run downhill which incorporated an extensive amount of eccentric work. Soreness was diffuse throughout the posterior region of the lower leg. In order to interpret what increased technetium uptake reflects and to express extreme endurance related damages, a biopsy was taken from the 3-D position of abnormal uptake. In addition, intramuscular pressures were determined in the deep posterior compartment. Scintigraphs revealed increased technetium pyrophosphate uptake in the medial portion of the gastrocnemius muscle. For 3698 fibres analysed, 33 fibres (1%) were necrotic, while a few other fibres were either atrophic or irregular shaped. A cluster of necrotic fibres occurred at the fascicular periphery for one subject and fibre type grouping occurred for another. Ultrastructural analysis revealed Z-line streaming near many capillaries and variously altered subsarcolemmal mitochondria including some with paracrystalline inclusions. The majority of the capillaries included thickened and irregular shaped endothelial cells. Intramuscular pressures of the deep posterior compartment were slightly elevated (12-15 mmHg) for three of the four subjects. Increased technetium uptake following extreme endurance running does not just reflect muscle necrosis but also subtle fibre abnormalities. Collectively, these pathological findings are attributed to relative ischaemia occurring during the race and during pre-race training, whereas, intramuscular pressure elevations associated with muscle soreness are attributed to mechanical stress caused by extensive eccentric work during the race.
Publication Date: Jun 01, 1993
Document ID:
20050000461
(Acquired Jan 06, 2005)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Acta physiologica Scandinavica (ISSN 0001-6772); Volume 148; 2; 187-98
Publisher Information: United Kingdom
Contract/Grant/Task Num: AM-25501
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: METABOLISM; MORPHOLOGY; MUSCLES; PATHOLOGY; PHYSICAL EXERCISE; PHYSICAL WORK; TECHNETIUM; ADULTS; AEROSPACE MEDICINE; BIOASTRONAUTICS; ELECTRON MICROSCOPY; MALES; NECROSIS; PAIN; PHYSICAL FITNESS; RUNNING
Other Descriptors: EXERTION; MUSCLES/METABOLISM/PATHOLOGY/PHYSIOPATHOLOGY; TECHNETIUM TC 99M PYROPHOSPHATE/PHARMACOKINETICS; ADULT; HUMAN; MALE; MICROSCOPY, ELECTRON; NECROSIS; PAIN; PHYSICAL ENDURANCE; PRESSURE; RADIONUCLIDE IMAGING; RUNNING; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S; NASA CENTER ARC; NASA DISCIPLINE CARDIOPULMONARY; NASA DISCIPLINE NUMBER 14-10; NASA PROGRAM SPACE PHYSIOLOGY AND COUNTERMEASURES
Availability Source: Other Sources
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