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Record Details

Record 24 of 1626
Effectiveness and duration of intramuscular antimotion sickness medications
Author and Affiliation:
Wood, C. D.(Louisiana State University Medical Center, Department of Pharmacology, Shreveport 71130)
Stewart, J. J.
Wood, M. J.
Mims, M.
Abstract: Motion sickness inhibits gastric motility, making the oral route ineffective for medications. The intramuscular route is an effective alternative. The rotating chair was used to produce the M 111 level of motion sickness on the Graybiel Symptom Scale. The intramuscular medications given 30 minutes before rotation were compared with placebo (saline, 1 mL) for effectiveness and duration in increasing the number of tolerated head movements. Average placebo number of head movements was 294. Promethazine 25 mg increased head movements by 78% (P < .05), with a duration of 12 hours. Scopolamine 0.2 mg increased head movements by 91% (P < .05), with a duration of 4 hours. The effect of caffeine 250 mg and ephedrine 25 mg was not significant. When combined with scopolamine, ephedrine produced an 32% additive effect. Scopolamine 0.08 mg, 0.1 mg, and 0.2 mg and also promethazine 12.5 mg and 25 mg were significant (P < .05). Promethazine appears to be the drug of choice for intramuscular use because of a longer duration and a high level of effectiveness. Scopolamine was of high effectiveness, but had a duration of 4 hours. It was eight times as potent by the intramuscular as by the oral route.
Publication Date: Nov 01, 1992
Document ID:
20050000573
(Acquired Jan 06, 2005)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Journal of clinical pharmacology (ISSN 0091-2700); Volume 32; 11; 1008-12
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ALCOHOLS; ANTIEMETICS AND ANTINAUSEANTS; CAFFEINE; HYOSCINE; MOTION SICKNESS; MOTION SICKNESS DRUGS; PHARMACOLOGY; PROMETHAZINE; ETIOLOGY; FEMALES; INJECTION; MALES; TIME DEPENDENCE
Other Descriptors: CAFFEINE/PHARMACOLOGY; EPHEDRINE/PHARMACOLOGY; MOTION SICKNESS/ETIOLOGY/PREVENTION & CONTROL; PROMETHAZINE/PHARMACOLOGY/THERAPEUTIC USE; SCOPOLAMINE/PHARMACOLOGY/THERAPEUTIC USE; COMPARATIVE STUDY; FEMALE; HUMAN; INJECTIONS, INTRAMUSCULAR; MALE; TIME FACTORS; NASA DISCIPLINE NEUROSCIENCE; NON-NASA CENTER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL
Availability Source: Other Sources
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