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Distribution of iodine into blood components of the Sprague-Dawley rat differs with the chemical form administeredIt has been reported previously that radioactivity derived from iodine distributes differently in the Sprague-Dawley rat depending on the chemical form administered (Thrall and Bull, 1990). In the present communication we report the differential distribution of radioactivity derived from iodine (I2) and iodide (I-) into blood components. Twice as much radioiodine is in the form of I- in the plasma of animals treated with 125I- compared to 125I2-treated rats. No I2 could be detected in the plasma. With an increase in dose, increasing amounts of radioactivity derived from 125I2-treated animals distribute to whole blood compared to equivalent doses of 125I-, reaching a maxima at a dose of 15.8 mumol I/kg body weight. Most of the radioactivity derived from I2 associates with serum proteins and lipids, in particular with albumin and cholesteryl iodide. These data indicate a differential distribution of radioactivity depending on whether it is administered as iodide or iodine. This is inconsistent with the commonly held view that iodine (I2) is reduced to iodide (I-) before it is absorbed systemically from the gastrointestinal tract.
Document ID
20050000581
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Thrall, K. D.
(College of Pharmacy, Washington State University Pullman)
Bull, R. J.
Sauer, R. L.
Date Acquired
August 22, 2013
Publication Date
November 1, 1992
Publication Information
Publication: Journal of toxicology and environmental health
Volume: 37
Issue: 3
ISSN: 0098-4108
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Environmental Health

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