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decreased heterotopic osteogenesis in vitamin-d-deficient, but normocalcemic guinea pigsThe effect of vitamin D deficiency unhampered by hypocalcemia on de novo bone formation was studied in guinea pigs. Heterotopic induction of osteogenesis was evaluated 4 weeks after intramuscular transplantation of allogenic urinary bladder transitional epithelium from vitamin-D-repleted (+D) donors into +D and -D recipients. In -D recipients the frequency of osteogenesis and the amount of induced bone were significantly diminished; induced bone was less mature, scantly cellular woven bone poorly repopulated with bone marrow. No effect of vitamin D deficiency on orthotopic bone growth and on mineralization of orthotopic and heterotopically induced bone was observed. It is proposed that in addition to inducing factors (BMPs, growth factors) which may be responsible for transformation of mesenchymal cells to osteoprogenitor cells, normal concentrations of 1,25-(OH)2D3 may be required for proliferation and further differentiation of these cells into osteoblasts and for expression of genes engaged in extracellular matrix formation and maturation.
Document ID
20050000582
Document Type
Reprint (Version printed in journal)
Authors
Dziedzic-Goclawska, A.
(School of Medicine Warsaw, Poland)
Toverud, S. U.
Kaminski, A.
Boass, A.
Yamauchi, M.
Date Acquired
August 22, 2013
Publication Date
November 1, 1992
Publication Information
Publication: Bone and mineral
Volume: 19
Issue: 2
ISSN: 0169-6009
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AR 37604
CONTRACT_GRANT: AR 19969
CONTRACT_GRANT: DE 08522
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center