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System identification of perilymphatic fistula in an animal modelAn acute animal model has been developed in the chinchilla for the study of perilymphatic fistulas. Micropunctures were made in three sites to simulate bony, round window, and oval window fistulas. The eye movements in response to pressure applied to the external auditory canal were recorded after micropuncture induction and in preoperative controls. The main pressure stimulus was a pseudorandom binary sequence (PRBS) that rapidly changed between plus and minus 200 mm of water. The PRBS stimulus, with its wide frequency bandwidth, produced responses clearly above the preoperative baseline in 78 percent of the runs. The response was better between 0.5 and 3.3 Hz than it was below 0.5 Hz. The direction of horizontal eye movement was toward the side of the fistula with positive pressure applied in 92 percent of the runs. Vertical eye movements were also observed. The ratio of vertical eye displacement to horizontal eye displacement depended upon the site of the micropuncture induction. Thus, such a ratio measurement may be clinically useful in the noninvasive localization of perilymphatic fistulas in humans.
Document ID
Document Type
Reprint (Version printed in journal)
Wall, C. 3rd (Harvard Medical School Boston, Massachusetts 02114)
Casselbrant, M. L.
Date Acquired
August 22, 2013
Publication Date
September 1, 1992
Publication Information
Publication: The American journal of otology
Volume: 13
Issue: 5
ISSN: 0192-9763
Subject Category
Life Sciences (General)
Distribution Limits
Non-NASA Center
NASA Discipline Neuroscience