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Record Details

Record 17 of 7827
System identification of perilymphatic fistula in an animal model
Author and Affiliation:
Wall, C. 3rd(Harvard Medical School, Department of Otology and Laryngology, Boston, Massachusetts 02114)
Casselbrant, M. L.
Abstract: An acute animal model has been developed in the chinchilla for the study of perilymphatic fistulas. Micropunctures were made in three sites to simulate bony, round window, and oval window fistulas. The eye movements in response to pressure applied to the external auditory canal were recorded after micropuncture induction and in preoperative controls. The main pressure stimulus was a pseudorandom binary sequence (PRBS) that rapidly changed between plus and minus 200 mm of water. The PRBS stimulus, with its wide frequency bandwidth, produced responses clearly above the preoperative baseline in 78 percent of the runs. The response was better between 0.5 and 3.3 Hz than it was below 0.5 Hz. The direction of horizontal eye movement was toward the side of the fistula with positive pressure applied in 92 percent of the runs. Vertical eye movements were also observed. The ratio of vertical eye displacement to horizontal eye displacement depended upon the site of the micropuncture induction. Thus, such a ratio measurement may be clinically useful in the noninvasive localization of perilymphatic fistulas in humans.
Publication Date: Sep 01, 1992
Document ID:
20050000612
(Acquired Jan 06, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: The American journal of otology (ISSN 0192-9763); Volume 13; 5; 443-8
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ANIMALS; DISEASES; SYSTEM IDENTIFICATION; AUDITORY STIMULI; EYE MOVEMENTS; FEMALES; MALES; RODENTS
Other Descriptors: COCHLEAR DISEASES/DIAGNOSIS; DISEASE MODELS, ANIMAL; FISTULA/DIAGNOSIS; ACOUSTIC STIMULATION; ANIMALS; CHINCHILLA; ELECTROOCULOGRAPHY; EYE MOVEMENTS; FEMALE; MALE; PUNCTURES; SUPPORT, NON-U.S. GOV'T; NASA DISCIPLINE NEUROSCIENCE; NON-NASA CENTER
Availability Source: Other Sources
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