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Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patientsWe evaluated the effects of intermittent slow-release sodium fluoride (SRNaF) and continuous calcium citrate therapy on cortical bone histology, reflection ultrasound velocity (material strength) and back-scattered electron image analysis (BEI) in 26 osteoporotic patients before and following therapy. All measurements were made on transiliac crest bone biopsies obtained before and following 2 years of therapy in each patient. For all 26 patients there were no significant changes in cortical bone histomorphometric parameters. In 15 patients in whom bone material quality was assessed by reflection ultrasound, there was no change in velocity (4000 +/- 227 SD to 4013 +/- 240 m/s). BEI disclosed no mineralization defects or the presence of woven bone. Mean atomic number (density) of bone increased slightly, but significantly (9.261 +/- 0.311 to 9.457 +/- 0.223, P = 0.031). While these changes are less marked than those observed for cancellous bone, they indicate that this form of therapy does not adversely affect cortical bone remodelling.
Document ID
20050000655
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Zerwekh, J. E.
(University of Texas Southwestern Medical Center Dallas 72535-8885)
Antich, P. P.
Sakhaee, K.
Prior, J.
Gonzales, J.
Gottschalk, F.
Pak, C. Y.
Date Acquired
August 22, 2013
Publication Date
July 1, 1992
Publication Information
Publication: Bone and mineral
Volume: 18
Issue: 1
ISSN: 0169-6009
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: R01-AR16061
CONTRACT_GRANT: K04-DK01787
CONTRACT_GRANT: M01-RR00633
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center

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