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Record 4 of 1020
Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patients
External Online Source: doi:10.1016/0169-6009(92)90800-S
Author and Affiliation:
Zerwekh, J. E.(University of Texas Southwestern Medical Center, Center for Mineral Metabolism and Clinical Research, Dallas 72535-8885)
Antich, P. P.
Sakhaee, K.
Prior, J.
Gonzales, J.
Gottschalk, F.
Pak, C. Y.
Abstract: We evaluated the effects of intermittent slow-release sodium fluoride (SRNaF) and continuous calcium citrate therapy on cortical bone histology, reflection ultrasound velocity (material strength) and back-scattered electron image analysis (BEI) in 26 osteoporotic patients before and following therapy. All measurements were made on transiliac crest bone biopsies obtained before and following 2 years of therapy in each patient. For all 26 patients there were no significant changes in cortical bone histomorphometric parameters. In 15 patients in whom bone material quality was assessed by reflection ultrasound, there was no change in velocity (4000 +/- 227 SD to 4013 +/- 240 m/s). BEI disclosed no mineralization defects or the presence of woven bone. Mean atomic number (density) of bone increased slightly, but significantly (9.261 +/- 0.311 to 9.457 +/- 0.223, P = 0.031). While these changes are less marked than those observed for cancellous bone, they indicate that this form of therapy does not adversely affect cortical bone remodelling.
Publication Date: Jul 01, 1992
Document ID:
20050000655
(Acquired Jan 06, 2005)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Bone and mineral (ISSN 0169-6009); Volume 18; 1; 65-76
Publisher Information: Netherlands
Contract/Grant/Task Num: K04-DK01787; M01-RR00633; R01-AR16061
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: BONES; CITRATES; HISTOLOGY; OSTEOPOROSIS; PATIENTS; SODIUM FLUORIDES; ADULTS; AGE FACTOR; BONE MINERAL CONTENT; CHEMOTHERAPY; CITRIC ACID; FEMALES; MALES; PATHOLOGY; SPINE
Other Descriptors: BONE REMODELING/DRUG EFFECTS; CITRATES/ADMINISTRATION & DOSAGE/THERAPEUTIC USE; OSTEOPOROSIS/DRUG THERAPY/PATHOLOGY/PHYSIOPATHOLOGY; SODIUM FLUORIDE/ADMINISTRATION & DOSAGE/THERAPEUTIC USE; ADULT; AGED; BONE DENSITY/DRUG EFFECTS; CITRIC ACID; DELAYED-ACTION PREPARATIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMAN; MALE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL/DRUG THERAPY/PATHOLOGY/PHYSIOPATHOLOGY; SPINAL FRACTURES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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