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L-baclofen-sensitive GABAB binding sites in the medial vestibular nucleus localized by immunocytochemistryL-Baclofen-sensitive GABAB binding sites in the medial vestibular nucleus (MVN) were identified immunocytochemically and visualized ultrastructurally in L-baclofen-preinjected rats and monkeys, using a mouse monoclonal antibody with specificity for the p-chlorophenyl moiety of baclofen. Saline-preinjected animals showed no immunostain. In drug-injected animals, there was evidence for both pre- and postsynaptic GABAergic inhibition in MVN mediated by GABAB receptors. These neural elements could be utilized in control of velocity storage in the vestibulo-ocular reflex.
Document ID
20050000701
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Holstein, G. R.
(Mount Sinai School of Medicine New York 10029)
Martinelli, G. P.
Cohen, B.
Date Acquired
August 22, 2013
Publication Date
May 22, 1992
Publication Information
Publication: Brain research
Volume: 581
Issue: 1
ISSN: 0006-8993
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS-00294
CONTRACT_GRANT: NS-24656
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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