NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Crystal structure of four-stranded Oxytricha telomeric DNAThe sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 A resolution. The oligonucleotide forms hairpins, two of which join to make a four-stranded helical structure with the loops containing four thymine residues at either end. The guanine residues are held together by cyclic hydrogen bonding and an ion is located in the centre. The four guanine residues in each segment have a glycosyl conformation that alternates between anti and syn. There are two four-stranded molecules in the asymmetric unit showing that the structure has some intrinsic flexibility.
Document ID
20050000743
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Kang, C.
(Massachusetts Institute of Technology Cambridge 02139)
Zhang, X.
Ratliff, R.
Moyzis, R.
Rich, A.
Date Acquired
August 22, 2013
Publication Date
March 12, 1992
Publication Information
Publication: Nature
Volume: 356
Issue: 6365
ISSN: 0028-0836
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Exobiology
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available