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Record Details

Record 84 of 545
Crystal structure of four-stranded Oxytricha telomeric DNA
External Online Source: doi:10.1038/356126a0
Author and Affiliation:
Kang, C.(Massachusetts Institute of Technology, Department of Biology, Cambridge 02139)
Zhang, X.
Ratliff, R.
Moyzis, R.
Rich, A.
Abstract: The sequence d(GGGGTTTTGGGG) from the 3' overhang of the Oxytricha telomere has been crystallized and its three-dimensional structure solved to 2.5 A resolution. The oligonucleotide forms hairpins, two of which join to make a four-stranded helical structure with the loops containing four thymine residues at either end. The guanine residues are held together by cyclic hydrogen bonding and an ion is located in the centre. The four guanine residues in each segment have a glycosyl conformation that alternates between anti and syn. There are two four-stranded molecules in the asymmetric unit showing that the structure has some intrinsic flexibility.
Publication Date: Mar 12, 1992
Document ID:
20050000743
(Acquired Jan 06, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Nature (ISSN 0028-0836); Volume 356; 6365; 126-31
Publisher Information: United Kingdom
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: CRYSTAL STRUCTURE; DEOXYRIBONUCLEIC ACID; PROTOZOA; CRYSTALLIZATION; EXOBIOLOGY; MOLECULAR STRUCTURE; NUCLEIC ACIDS; PHYSICAL CHEMISTRY; TELOMERES; X RAY DIFFRACTION
Other Descriptors: DNA/CHEMISTRY; OXYTRICHA/GENETICS; ANIMALS; BASE SEQUENCE; CHEMISTRY, PHYSICAL; CRYSTALLIZATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; TELOMERE/ULTRASTRUCTURE; X-RAY DIFFRACTION; NASA DISCIPLINE EXOBIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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