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Record Details

Record 4 of 3451
Collagen cross-linking of skin in patients with amyotrophic lateral sclerosis
External Online Source: doi:10.1002/ana.410310313
Author and Affiliation:
Ono, S.(Dental Research Center, University of North Carolina 27599-7455)
Yamauchi, M.
Abstract: Collagen cross-links of skin tissue (left upper arm) from 11 patients with amyotrophic lateral sclerosis (ALS) and 9 age-matched control subjects were quantified. It was found that patients with ALS had a significant reduction in the content of an age-related, stable cross-link, histidinohydroxylysinonorleucine, that was negatively correlated with the duration of illness. The contents of sodium borohydride-reducible labile cross-links, dehydro-hydroxylysinonorleucine and dehydro-histidinohydroxymerodesmosine, were significantly increased and were positively associated with the duration of illness (r = 0.703, p less than 0.05 and r = 0.684, p less than 0.05, respectively). The results clearly indicate that during the course of ALS, the cross-linking pathway of skin collagen runs counter to its normal aging, resulting in a "rejuvenation" phenomenon of skin collagen. Thus, cross-linking of skin collagen is affected in ALS.
Publication Date: Mar 01, 1992
Document ID:
20050000746
(Acquired Jan 06, 2005)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Annals of neurology (ISSN 0364-5134); Volume 31; 3; 305-10
Publisher Information: United States
Contract/Grant/Task Num: DE 00233; DE 08522; DE 08611
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: COLLAGENS; CROSSLINKING; DISEASES; PATIENTS; SKIN (ANATOMY); SPINAL CORD; ADULTS; AGE FACTOR; AGING; ARM (ANATOMY); BOROHYDRIDES; FEMALES; HISTIDINE; MALES; NERVOUS SYSTEM; OXIDATION-REDUCTION REACTIONS
Other Descriptors: AMYOTROPHIC LATERAL SCLEROSIS/METABOLISM; COLLAGEN/METABOLISM; SKIN/CHEMISTRY; AGED; AGING/METABOLISM; ARM; BOROHYDRIDES; DESMOSINE/ANALOGS & DERIVATIVES/ANALYSIS; DIPEPTIDES/ANALYSIS; FEMALE; HISTIDINE/ANALOGS & DERIVATIVES/ANALYSIS; HUMAN; MALE; MIDDLE AGED; MUSCULAR DISEASES/METABOLISM; NERVOUS SYSTEM DISEASES/METABOLISM; OXIDATION-REDUCTION; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER
Availability Source: Other Sources
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