NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Collagen cross-linking of skin in patients with amyotrophic lateral sclerosisCollagen cross-links of skin tissue (left upper arm) from 11 patients with amyotrophic lateral sclerosis (ALS) and 9 age-matched control subjects were quantified. It was found that patients with ALS had a significant reduction in the content of an age-related, stable cross-link, histidinohydroxylysinonorleucine, that was negatively correlated with the duration of illness. The contents of sodium borohydride-reducible labile cross-links, dehydro-hydroxylysinonorleucine and dehydro-histidinohydroxymerodesmosine, were significantly increased and were positively associated with the duration of illness (r = 0.703, p less than 0.05 and r = 0.684, p less than 0.05, respectively). The results clearly indicate that during the course of ALS, the cross-linking pathway of skin collagen runs counter to its normal aging, resulting in a "rejuvenation" phenomenon of skin collagen. Thus, cross-linking of skin collagen is affected in ALS.
Document ID
20050000746
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Ono, S.
(Dental Research Center, University of North Carolina 27599-7455)
Yamauchi, M.
Date Acquired
August 22, 2013
Publication Date
March 1, 1992
Publication Information
Publication: Annals of neurology
Volume: 31
Issue: 3
ISSN: 0364-5134
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DE 00233
CONTRACT_GRANT: DE 08522
CONTRACT_GRANT: DE 08611
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

Available Downloads

There are no available downloads for this record.
No Preview Available