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Changes in skeletal muscle gene expression consequent to altered weight bearingSkeletal muscle is a dynamic organ that adapts to alterations in weight bearing. This brief review examines changes in muscle gene expression resulting from the removal of weight bearing by hindlimb suspension and from increased weight bearing due to eccentric exercise. Acute (less than or equal to 2 days) non-weight bearing of adult rat soleus muscle alters only the translational control of muscle gene expression, while chronic (greater than or equal to 7 days) removal of weight bearing appears to influence pretranslational, translational, and posttranslational mechanisms of control. Acute and chronic eccentric exercise are associated with alterations of translational and posttranslational control, while chronic eccentric training also alters the pretranslational control of muscle gene expression. Thus alterations in weight bearing influence multiple sites of gene regulation.
Document ID
Document Type
Reprint (Version printed in journal)
Booth, F. W.
(University of Texas Medical School Houston 77225)
Kirby, C. R.
Date Acquired
August 22, 2013
Publication Date
March 1, 1992
Publication Information
Publication: The American journal of physiology
Volume: 262
Issue: 3 Pt 2
ISSN: 0002-9513
Subject Category
Life Sciences (General)
Funding Number(s)
Distribution Limits
NASA Discipline Musculoskeletal
Non-NASA Center
Review, Tutorial

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