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Preliminary evidence for a postsynaptic action of beta-bungarotoxin in mammalian skeletal muscleTwo hours after treatment with beta-bungarotoxin (0.34-0.4 microM), when there was complete neuromuscular block, the peak contracture response to 50 microM succinylcholine was significantly reduced by about 35% in the mouse phrenic nerve-diaphragm preparation. Additionally, significant phospholipase A2 activity was detected on primary cell cultures from skeletal muscle which were incubated for 2 hr with concentrations of beta-bungarotoxin greater than or equal to 0.1 microM. Thus, beta-bungarotoxin appears to have pharmacologically and biochemically detectable postsynaptic actions in mammalian muscle systems.
Document ID
20050000759
Document Type
Reprint (Version printed in journal)
Authors
Storella, R. J. (Hahnemann University Philadelphia, PA 19102)
Schouchoff, A. L.
Fujii, M.
Hill, J.
Fletcher, J. E.
Jiang, M. S.
Smith, L. A.
Date Acquired
August 22, 2013
Publication Date
March 1, 1992
Publication Information
Publication: Toxicon : official journal of the International Society on Toxinology
Volume: 30
Issue: 3
ISSN: 0041-0101
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal