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Low-dosage micronized 17 beta-estradiol prevents bone loss in postmenopausal womenWith the use of a double-blind, randomized, dose-ranging design, we tested during an 18-month period the degree of protection against postmenopausal bone loss afforded by micronized 17 beta-estradiol in dosages of 0.5, 1.0, and 2.0 mg. All subjects received supplementation to ensure a minimum of 1500 mg calcium daily. Fifty-one subjects completed at least 1 year of follow-up bone density measurements by quantitative computed tomography and by single- and dual-photon absorptiometry. In the placebo group spinal trabecular bone density decreased 4.9% annually (p less than 0.001), whereas in those taking micronized 17 beta-estradiol bone density tended to increase (annual increases of 0.3% in the 0.5 mg micronized 17 beta-estradiol group, 1.8% in the 1.0 mg micronized 17 beta-estradiol group, and 2.5% in the 2.0 mg micronized 17 beta-estradiol group). After completing the double-blind phase, 41 subjects completed an additional 18 months of follow-up while taking 1.0 mg micronized 17 beta-estradiol. During this time one third of the subjects were randomly assigned to discontinue calcium supplements. Among those who previously received placebo, trabecular bone density increased 4.3% annually, whereas among those who had used micronized 17 beta-estradiol, trabecular bone density response was inversely related to the dosage previously used. Additionally and independently, the level of calcium intake showed a statistically significant correlation with the change in spinal trabecular bone density (r = 0.37, p = 0.02). We conclude that micronized 17 beta-estradiol has a continuous skeletal dose-response effect in the range of 0.5 to 2.0 mg and that calcium intake positively modifies the skeletal response to 1.0 mg micronized 17 beta-estradiol.
Document ID
20050000789
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ettinger, B.
(Kaiser Permanente Medical Care Program Oakland, CA 94611-5463)
Genant, H. K.
Steiger, P.
Madvig, P.
Date Acquired
August 22, 2013
Publication Date
February 1, 1992
Publication Information
Publication: American journal of obstetrics and gynecology
Volume: 166
Issue: 2
ISSN: 0002-9378
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Randomized Controlled Trial
Non-NASA Center
Clinical Trial
NASA Discipline Musculoskeletal

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