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Caffeine potentiates the enhancement by choline of striatal acetylcholine releaseWe investigated the effect of peripherally administered caffeine (50 mg/kg), choline (30, 60, or 120 mg/kg) or combinations of both drugs on the spontaneous release of acetylcholine (ACh) from the corpus striatum of anesthetized rats using in vivo microdialysis. Caffeine alone or choline in the 30 or 60 mg/kg dose failed to increase ACh in microdialysis samples; the 120 mg/kg choline dose significantly enhanced ACh during the 80 min following drug administration. Coadministration of caffeine with choline significantly increased ACh release after each of the choline doses tested. Peak microdialysate levels with the 120 mg/kg dose were increased 112% when caffeine was additionally administered, as compared with 54% without caffeine. These results indicate that choline administration can enhance spontaneous ACh release from neurons, and that caffeine, a drug known to block adenosine receptors on these neurons, can amplify the choline effect.
Document ID
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Johnson, D. A.
(Interneuron Pharmaceuticals Inc. Lexington, MA 02173)
Ulus, I. H.
Wurtman, R. J.
Date Acquired
August 22, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Life sciences
Volume: 51
Issue: 20
ISSN: 0024-3205
Subject Category
Life Sciences (General)
Distribution Limits
Non-NASA Center
NASA Discipline Regulatory Physiology

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