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The statistical analysis of circadian phase and amplitude in constant-routine core-temperature dataAccurate estimation of the phases and amplitude of the endogenous circadian pacemaker from constant-routine core-temperature series is crucial for making inferences about the properties of the human biological clock from data collected under this protocol. This paper presents a set of statistical methods based on a harmonic-regression-plus-correlated-noise model for estimating the phases and the amplitude of the endogenous circadian pacemaker from constant-routine core-temperature data. The methods include a Bayesian Monte Carlo procedure for computing the uncertainty in these circadian functions. We illustrate the techniques with a detailed study of a single subject's core-temperature series and describe their relationship to other statistical methods for circadian data analysis. In our laboratory, these methods have been successfully used to analyze more than 300 constant routines and provide a highly reliable means of extracting phase and amplitude information from core-temperature data.
Document ID
20050000825
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Brown, E. N.
(Harvard Medical School, Brigham and Women's Hospital Boston, Massachusetts 02115)
Czeisler, C. A.
Date Acquired
August 22, 2013
Publication Date
September 1, 1992
Publication Information
Publication: Journal of biological rhythms
Volume: 7
Issue: 3
ISSN: 0748-7304
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NIDDK 5-T32-DK-07529
CONTRACT_GRANT: NIA-1-R01-AG06072
CONTRACT_GRANT: NIGM 2T GM07753-06
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center

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