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Extracellular matrix and cell shape: potential control points for inhibition of angiogenesisCapillary endothelial (CE) cells require two extracellular signals in order to switch from quiescence to growth and back to differentiation during angiogenesis: soluble angiogenic factors and insoluble extracellular matrix (ECM) molecules. Soluble endothelial mitogens, such as basic fibroblast growth factor (FGF), act over large distances to trigger capillary growth, whereas ECM molecules act locally to modulate cell responsiveness to these soluble cues. Recent studies reveal that ECM molecules regulate CE cell growth and differentiation by modulating cell shape and by activating intracellular chemical signaling pathways inside the cell. Recognition of the importance of ECM and cell shape during capillary morphogenesis has led to the identification of a series of new angiogenesis inhibitors. Elucidation of the molecular mechanism of capillary regulation may result in development of even more potent angiogenesis modulators in the future.
Document ID
20050000838
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Ingber, D.
(Children's Hospital Boston, MA 02115)
Date Acquired
August 22, 2013
Publication Date
November 1, 1991
Publication Information
Publication: Journal of cellular biochemistry
Volume: 47
Issue: 3
ISSN: 0730-2312
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: PO1-CA45448
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Review
NASA Discipline Cell Biology
Review, Tutorial

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