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Elevated central venous pressure: a consequence of exercise training-induced hypervolemia?Resting blood volumes and arterial and central venous pressures (CVP) were measured in 14 men before and after exercise training to determine whether training-induced hypervolemia is accompanied by a change in total vascular capacitance. In addition, resting levels of plasma arginine vasopressin (AVP), atrial natriuretic peptide (ANP), aldosterone (Ald), and norepinephrine (NE) were measured. The same measurements were conducted in seven subjects who did not undergo exercise and acted as controls. Exercise training consisted of 10 wk of controlled cycle exercise for 30 min/day, 4 days/wk at 75-80% of maximal O2 uptake (VO2max). A training effect was verified by a 20% increase in VO2max, a resting bradycardia, and a 9% increase in blood volume. Mean arterial blood pressure was unaltered by exercise training, but resting CVP increased by 16% (P less than 0.05). The percent change in blood volume from before to after training was linearly related to the percent change in CVP (r = 0.903, P less than 0.05). As a consequence of elevations in both blood volume and CVP, the volume-to-pressure ratio was unchanged after exercise training. Plasma AVP, ANP, Ald, and NE were unaltered. Our results indicate that elevated CVP is a consequence of training-induced hypervolemia without alteration in total effective venous capacitance.
Document ID
Document Type
Reprint (Version printed in journal)
Convertino, V. A.
(NASA Kennedy Space Center Cocoa Beach, FL United States)
Mack, G. W.
Nadel, E. R.
Date Acquired
August 22, 2013
Publication Date
February 1, 1991
Publication Information
Publication: The American journal of physiology
Volume: 260
Issue: 2 Pt 2
ISSN: 0002-9513
Subject Category
Aerospace Medicine
Distribution Limits
NASA Program Space Physiology and Countermeasures
NASA Discipline Cardiopulmonary
NASA Discipline Number 14-10

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