NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Detection of a human intracisternal A-type retroviral particle antigenically related to HIVSjogren's syndrome is an autoimmune disease that is characterized by dryness of the mouth and eyes. The loss of salivary and lacrimal gland function is accompanied by lymphocytic infiltration. Because similar symptoms and glandular pathology are observed in certain persons infected with human immunodeficiency virus (HIV), a search was initiated for a possible retroviral etiology in this syndrome. A human intracisternal A-type retroviral particle that is antigenically related to HIV was detected in lymphoblastoid cells exposed to homogenates of salivary tissue from patients with Sjogren's syndrome. Comparison of this retroviral particle to HIV indicates that they are distinguishable by several ultrastructural, physical, and enzymatic criteria.
Document ID
20050000868
Document Type
Reprint (Version printed in journal)
Authors
Garry, R. F. (Tulane University School of Medicine New Orleans, LA 70112)
Fermin, C. D.
Hart, D. J.
Alexander, S. S.
Donehower, L. A.
Luo-Zhang, H.
Date Acquired
August 22, 2013
Publication Date
November 23, 1990
Publication Information
Publication: Science
Volume: 250
Issue: 4984
ISSN: 0036-8075
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AI 28048
CONTRACT_GRANT: AI 22720
CONTRACT_GRANT: DC 00712
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience