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Cosmos 1887: morphology, histochemistry, and vasculature of the growing rat tibiaLight microscopy, electron microscopy, and enzyme histochemistry were used to study the effects of spaceflight on metaphyseal and cortical bone of the rat tibia. Cortical cross-sectional area and perimeter were not altered by a 12.5-day spaceflight in 3-month-old male rats. The endosteal osteoblast population and the vasculature near the periosteal surface in flight rats compared with ground controls showed more pronounced changes in cortical bone than in metaphyseal bone. The osteoblasts demonstrated greater numbers of transitional Golgi vesicles, possibly caused by a decreased cellular metabolic energy source, but no difference in the large Golgi saccules or the cell membrane-associated alkaline phosphatase activity. The periosteal vasculature in the diaphysis of flight rats often showed lipid accumulations within the lumen of the vessels, occasional degeneration of the vascular wall, and degeneration of osteocytes adjacent to vessels containing intraluminal deposits. These changes were not found in the metaphyseal region of flight animals. The focal vascular changes may be due to ischemia of bone or a developing fragility of the vessel walls as a result of spaceflight.
Document ID
20050000892
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Doty, S. B.
(Columbia University New York, New York 10032)
Morey-Holton, E. R.
Durnova, G. N.
Kaplansky, A. S.
Date Acquired
August 22, 2013
Publication Date
January 1, 1990
Publication Information
Publication: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume: 4
Issue: 1
ISSN: 0892-6638
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Flight Experiment
NASA Experiment Number COS 1887-3
Cosmos 1887 Project
NASA Discipline Number 26-20
NASA Discipline Number 00-00
NASA Program Flight
NASA Discipline Developmental Biology
short duration
unmanned
NASA Program Space Biology
NASA Center ARC

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