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Beat to beat variability in cardiovascular variables: noise or music?Cardiovascular variables such as heart rate, arterial blood pressure, stroke volume and the shape of electrocardiographic complexes all fluctuate on a beat to beat basis. These fluctuations have traditionally been ignored or, at best, treated as noise to be averaged out. The variability in cardiovascular signals reflects the homeodynamic interplay between perturbations to cardiovascular function and the dynamic response of the cardiovascular regulatory systems. Modern signal processing techniques provide a means of analyzing beat to beat fluctuations in cardiovascular signals, so as to permit a quantitative, noninvasive or minimally invasive method of assessing closed loop hemodynamic regulation and cardiac electrical stability. This method promises to provide a new approach to the clinical diagnosis and management of alterations in cardiovascular regulation and stability.
Document ID
20050000899
Document Type
Reprint (Version printed in journal)
Authors
Appel, M. L.
(Massachusetts Institute of Technology Cambridge 02139)
Berger, R. D.
Saul, J. P.
Smith, J. M.
Cohen, R. J.
Date Acquired
August 22, 2013
Publication Date
November 1, 1989
Publication Information
Publication: Journal of the American College of Cardiology
Volume: 14
Issue: 5
ISSN: 0735-1097
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 1R01-HL39291-01
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Review, Tutorial
Review
NASA Discipline Cardiopulmonary
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