NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Myoneural necrosis following high-frequency electrical stimulation of the cast-immobilized rabbit hindlimbThe morphological and physiological effects of 4 weeks of high-frequency electrical stimulation (1 h/day, 5 days/week) on cast-immobilized rabbit hindlimbs were investigated in the tibialis anterior muscle and peroneal nerve. In 2 out of 6 animals, high-frequency stimulation with immobilization caused muscle fiber death, internalization of muscle fiber nuclei, connective tissue proliferation, inflammatory response, altered fiber size distribution and variable staining intensities. The fast-twitch fibers were predominantly affected. Two of six peripheral nerves subjected to immobilization and stimulation showed severe damage. Tetanic forces were significantly reduced in the affected muscles. Therefore, the immobilization and high-frequency stimulation may be detrimental to myoneural structure and function and, thus, this combination of therapies should be applied conservatively.
Document ID
20050000912
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Friden, J.
(Umea University Hospital Sweden)
Lieber, R. L.
Myers, R. R.
Powell, H. C.
Hargens, A. R.
Date Acquired
August 22, 2013
Publication Date
January 1, 1989
Publication Information
Publication: Stereotactic and functional neurosurgery
Volume: 53
Issue: 4
ISSN: 1011-6125
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal
NASA Program Biomedical Research
NASA Discipline Number 26-10

Available Downloads

There are no available downloads for this record.
No Preview Available