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Hematological measurements in rats flown on Spacelab shuttle, SL-3Previous studies have shown that a decrease in red cell mass occurs in astronauts, and some studies indicate a leukocytosis occurs. A life science module housing young and mature rats was flown on shuttle mission Spacelab 3 (SL-3), and the results of hematology studies of flight and control rats are presented. Statistically significant increases in the hematocrit, red blood cell counts, and hemoglobin determinations, together with a mild neutrophilia and lymphopenia, were found in flight animals. No significant changes were found in bone marrow and spleen cell differentials or erythropoietin determinations. Clonal assays demonstrated an increased erythroid colony formation of flight animal bone marrow cells at erythropoietin doses of 0.02 and 1.0 U/ml but not 0.20 U/ml. These results agree with some but vary from other previously published studies. Erythropoietin assays and clonal studies were performed for the first time.
Document ID
Document Type
Reprint (Version printed in journal)
Lange, R. D.
Andrews, R. B.
Gibson, L. A.
Congdon, C. C.
Wright, P.
Dunn, C. D.
Jones, J. B.
Date Acquired
August 22, 2013
Publication Date
February 1, 1987
Publication Information
Publication: The American journal of physiology
Volume: 252
Issue: 2 Pt 2
ISSN: 0002-9513
Subject Category
Life Sciences (General)
Distribution Limits
NASA Experiment Number SL3-26
short duration
Flight Experiment
STS-51B Shuttle Project
Cosmos Project
Non-NASA Center
NASA Discipline Regulatory Physiology

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