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Review of the biological effects of weightlessness on the human endocrine systemStudies from space flights over the past two decades have demonstrated that there are basic physiological changes in humans during space flight. These changes include cephalad fluid shifts, loss of fluid and electrolytes, loss of muscle mass, space motion sickness, anemia, reduced immune response, and loss of calcium and mineralized bone. The cause of most of these manifestations is not known but the general approach has been to investigate systemic and hormonal changes. However, data from the 1973-1974 Skylabs, Spacelab 3 (SL-3), Spacelab D-I (SL-DI), and now the new SLS-1 missions support a more basic biological response to microgravity that may occur at the tissue, cellular, and molecular level. This report summarizes ground-based and SLS-1 experiments that examined the mechanism of loss of red blood cell mass in humans, the loss of bone mass and lowered osteoblast growth under space flight conditions, and loss of immune function in microgravity.
Document ID
20050003464
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hughes-Fulford, M.
(Veteran's Administration Medical Center San Francisco, CA)
Date Acquired
August 22, 2013
Publication Date
September 1, 1993
Publication Information
Publication: Receptor
Volume: 3
Issue: 3
ISSN: 1052-8040
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
STS-40 Shuttle Project
NASA Discipline Number 00-00
NASA Program Flight
Flight Experiment
NASA Discipline General Space Life Sciences
short duration
manned
Non-NASA Center
Review, Tutorial
Review

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