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Glucose absorption, hormonal release and hepatic metabolism after guar gum ingestionSix non-anaesthetized Large White pigs (mean body weight 59 +/- 1.7 kg) were fitted with permanent catheters in the portal vein, the brachiocephalic artery and the right hepatic vein and with electromagnetic flow probes around the portal vein and the hepatic artery. The animals were provided a basal none-fibre diet (diet A) alone or together with 6% guar gum (diet B) or 15% purified cellulose (diet C). The diets were given for 1 week and according to a replicated 3 x 3 latin-square design. On the last day of each adaptation period test meals of 800 g were given prior to blood sampling. The sampling was continued for 8 h. Guar gum strongly reduced the glucose absorption as well as the insulin, gastric inhibitory polypeptide (GIP) and insulin-like growth factor-1 (IGF-1) production. However, the reduction in peripheral blood insulin levels caused by guar gum was not associated with a change in hepatic insulin extraction. IGF-1 appeared to be strongly produced by the gut. The liver had a net uptake of the peptide. Ingestion of guar gum increased the hepatic extraction coefficient of gut produced IGF-1. Guar gum ingestion also appeared to decrease pancreatic glucagon secretion. Cellulose at the level consumed had very little effect on the parameters considered. It is suggested that the modulation of intestinal mechanisms by guar gum was sufficient to mediate the latter internal metabolic effects.
Document ID
20050010651
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Simoes Nunes, C.
(NASA Headquarters Washington, DC United States)
Malmlof, K.
Date Acquired
August 22, 2013
Publication Date
January 1, 1992
Publication Information
Publication: Reproduction, nutrition, development
Volume: 32
Issue: 1
ISSN: 0926-5287
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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